A family of ras-like GTP-binding proteins expressed in electromotor neurons
نویسندگان
چکیده
منابع مشابه
The Rheb family of GTP-binding proteins.
Rheb proteins represent a novel and unique family of the Ras superfamily GTP-binding proteins that is conserved from yeast to human. Biochemical studies establish that they bind and hydrolyze GTP. Molecular modeling studies reveal a few structural differences between Rheb and Ras, which may suggest that residues involved in biochemical activities differ between the two G-proteins. The function ...
متن کاملEmerging concepts in the Ras superfamily of GTP-binding proteins.
The Ras superfamily of GTP-binding proteins (> 50 members) regulates a diverse spectrum of intracellular processes. These include cellular proliferation and differentiation, intracellular vesicular trafficking, cytoskeletal control, NADPH oxidase function, as well as others. In this review, we describe recent progress and emerging themes in the action and regulation of these important cellular ...
متن کاملThe ras superfamily of GTP-binding proteins: guidelines on nomenclature.
Over the past several years, a large superfamily of monomeric GTP-binding proteins structurally related to the ras oncogene proteins has been described (1-4). The number of members of this superfamily identified has increased dramatically in recent years, and the number of descriptive terms or names used to denote these proteins has increased almost as dramatically as well. During the recent FA...
متن کاملEvolution of the Rab family of small GTP-binding proteins.
Rab proteins are small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane-associated molecular switches. Here, we have identified the complete Rab families in the Caenorhabditis elegans (29 members), Drosophila melanogaster (29), Homo sapiens (60) and Arabidopsis thaliana (57), and we defined c...
متن کاملBiology of the Rap proteins, members of the ras superfamily of GTP-binding proteins.
A large superfamily (> 50 members) of monomeric GTPbinding proteins structurally related to the ras oncogene proteins has been described in the past few years (Bourne et al., 1991; Grand and Owen, 1991; Hall, 1990; Valencia et al., 1991). These proteins have been implicated in the regulation of a diverse array of cellular processes, utilizing their ability to bind and hydrolyse GTP as a means t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)52297-3